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Some agents in this class (liraglutide, semaglutide, and dulaglutide) have demonstrated cardiovascular benefits in patients with established cardiovascular disease, while exenatide showed a neutral effect in cardiovascular outcome trials

Subjects from the PIONNEER 7 study showed comparable satisfaction between oral semaglutide and sitagliptin [41], a dipeptidyl peptidase-4 inhibitor (DPP-4i) largely used in monotherapy or combination when first-line treatment does not achieve adequate glycaemic control, but sitagliptin does not provide any cardiovascular benefit [95]

Global J Pharmacol

T.CamilleriM.McKinzieS.BurtonD.CarlsonP.BusciglioI